AN OBSERVATIONAL STUDY OF ASSOCIATION OF SUBCLINICAL HYPOTHYROIDSIM AND ABNORMAL UTERINE BLEEDING

Abstract

Introduction Abnormal uterine bleeding is a common gynecological presentation, accounting for atleast 20% of all new outpatient visits. It has been recognized that thyroid dysfunction may have profound effects on the female reproductive system. Both hypothyroidism and hyperthyroidism are associated with a variety of changes, including delayed onset of puberty anovulatory cycles, and abnormally high fetal wastage. Hence,this study was conducted to know the thyroid status of the patient with abnormal uterine bleeding. Aim & Objective: 1. To estimate the Prevalence & association of subclinical hypothyroidism among women presenting with abnormal uterine bleeding.Methods: A descriptive cross-sectional study was conducted in 250 patients with abnormal uterine bleeding in a tertiary care hospital. Data was collected using a questionnaire which includes patients prole ,the pattern of abnormal uterine bleeding, and thyroid prole. Settings and Design: This study was done in a MGM medical college indore & myh hospital in Madhya Pradesh. Results: Out of 250 patients presenting with AUB, 163 (71.6%) were euthyroid, 20 (3.6%) were overt hypothyroid, and 10 (0.5%) was hyperthyroidism and 57 ( 24.2%) were subclinical hypothyroidsim. the mean levels of the thyroid-stimulating hormone were 4.28 ± 2.76 mIU/L. The mean triiodothyronine and thyroxine were 132.6 ± 34.90 and 9.81 ± 3.60, respectively The most common symptom abnormal uterine bleeding was menorrhagia 74 (29.8%), followed by polymenorrhoea 53 (21.4%), hypomenorrhoea 32 (12.9%) , intermenstrual bleeding 31(12.5%), acyclicalbleeding 6 (2.8%) and oligomenorrhea 3 (1.2%). The maximum number of patients was between 41-50 years with the mean age of 41years. Conclusion: There is signicant association between subclinical hypothyroidism and abnormal uterine bleeding The prevalence of subclinical hypothyroidism in the study group was 24.2% It is suggested that women with early onset menorrhagia and oligomenorrhea with or without symptoms & signs attributable to thyroid dysfunction should be offered thyroid function testing to detect subclinical stage Early detection by selective screening and specic pharmacotherapy for subclinical thyroid disease early in the course of the disease will prove to be a superior alternative to surgical treatments like hysterectomy