Abstract
An ion-selective membrane electrode (ISE) was developed for estimation of drotaverine hydrochloride by direct potentiometry and potentiometric depositional titration. The ISE reacted reversibly to changes in the potential-determining ion concentration over the range 5 × 10− 2 to 7.9 × 10− 6 M, the detection limit was (4.3 ± 0.2) × 10− 6 M, and the electrode function slope was 58 ± 2 mV/pC. A method for the potentiometric estimation of drotaverine hydrochloride in tablets and solutions for injection is proposed.
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