Abstract
The electrochemical redox behavior of three trinuclear Ni(II) complexes [Ni3(abb)3(H2O)3(µ-ttc)](ClO4)3 (1), [Ni3(tebb)3(H2O)3(µ-ttc)](ClO4)3·H2O (2), and [Ni3(pmdien)3(µ-ttc)](ClO4)3 (3), where abb = 1-(1H-benzimidazol-2-yl)-N-(1H-benzimidazol-2-ylmethyl)methan-amine, ttcH3 = trithiocyanuric acid, tebb = 2-[2-[2-(1H-benzimidazol-2-yl)ethylsulfanyl]ethyl]-1H-benzimidazole, and pmdien = N,N,N′,N″,N″-pentamethyldiethylenetriamine is reported. Cyclic voltammetry (CV) was applied for the study of the electrochemical behavior of these compounds. The results confirmed the presence of ttc and nickel in oxidation state +2 in the synthesized complexes. Moreover, the antibacterial properties and cytotoxic activity of complex 3 was investigated. All the complexes show antibacterial activity against Staphylococcus aureus and Escherichia coli to different extents. The cytotoxic activity of complex 3 and ttcNa3 were studied on G-361, HOS, K-562, and MCF7 cancer cell lines. It was found out that complex 3 possesses the cytotoxic activity against the tested cell lines, whereas ttcNa3 did not show any cytotoxic activity.
Highlights
Trithiocyanuric acid is an organic heterocyclic compound that consists of triazine ring and three sulfurs on carbon atoms
The Cyclic voltammetry (CV) of complex 1 differs to the other complexes as only one reversible couple can be observed about −0.2 V, which might be due to the redox of the nickel
Nickel chloride as well as pmdien have no antibacterial activities. When we compare these findings with antibacterial activity of complex 1 [27], it can be concluded that the ligand abb and especially its nickel complex have much better activities against S. aureus and comparable antibacterial activity on E. coli
Summary
Trithiocyanuric acid (trimercaptotriazine acid, ttc) is an organic heterocyclic compound that consists of triazine ring and three sulfurs on carbon atoms. Metal ions can be coordinated by sulfur or nitrogen atom of ttc only to form mononuclear to trinuclear complexes; even more complicated compounds were prepared, such as hexanuclear gold(I). A later study on coordination properties of nickel ttc shows the possibility of preparing even heptanuclear cluster. Coordination properties of nickel ttc [Ni shows the possibility of preparing even heptanuclear cluster. Platinum-based is chemotherapy failure might be attributed to tumor resistance to oxaliplatin [23,24] It has not effective against many common types of cancer. For it has beenInhighly important to find 2+, Fe2+, and Mn2+ involving ttc ions reported synthesis and study on mixed ligand complexes with. We studied antibacterial and studied antibacterial and cytotoxic activities of complexes and 2, for butcomplex such data were cytotoxic activities of complexes
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