Abstract
There is overwhelming evidence that the pituitary hormone prolactin (PRL) plays a crucial role in the pathogenesis of mammary cancers in rodents [1]. The role of PRL in human breast cancer, however, has remained uncertain. Numerous studies where blood levels of PRL have been measured have uniformly observed that PRL levels remain largely unaltered in patients with breast cancer [2]. Various other investigations have also failed to implicate PRL in the human disease. Nevertheless, it is believed at the present time that PRL does play a role in human breast cancer, but that its precise mechanism of involvement has not been elucidated.
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