Abstract
Phylogenetic profiling and gene expression analysis of yeast proteins suggests that the nucleolus probably evolved from an archaeal-type ribosome maturation machinery by recruitment of several bacterial-type and mostly eukaryote-specific factors
Highlights
Baker's yeast is a primary model organism for research on eukaryotic ribosome assembly and nucleoli, the list of its proteins that are functionally associated with nucleoli or ribosomes is still incomplete
The nucleolus is a dense compartment in the nucleus of eukaryotes where freshly transcribed ribosomal RNA and ribosomal proteins imported from the cytosol meet complex machinery for ribosome maturation and assembly
We describe a comprehensive list of yeast proteins that we predict to be associated with nucleolar or ribosomal components
Summary
Baker's yeast is a primary model organism for research on eukaryotic ribosome assembly and nucleoli, the list of its proteins that are functionally associated with nucleoli or ribosomes is still incomplete. We trained a naïve Bayesian classifier to predict novel proteins that are associated with yeast nucleoli or ribosomes based on parts lists of nucleoli in model organisms and large-scale protein interaction data sets. Ribosomal subunits leave the nucleolus in a state in which the majority of their building blocks are already incorporated [2,3]. Several lines of evidence suggest that ribosome biosynthesis is not the sole function of nucleoli. They have been linked to Genome Biology 2006, 7:R98
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
