Abstract
The nonionic triblock copolymer poloxamer 188 (P188) and similar surfactants has been shown to seal disrupted cell membranes after physical disruption by physical trauma or lipid peroxidation. Here we used T2-MRI to quantify the edema caused by pure electroporation mediated rat skeletal muscle membrane disruption in-situ to determine if muscle compartment edema could be averted. The rats were divided into three groups: lactated ringers (LR)-treated (as control); LR/P188-treated; and dextran-treated 0.5 hours after electroporation.
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