Abstract
Intracellular Ca2+ concentration oscillation is one of thetypical nonlinear dynamical phenomena in biophysics. According to theexperimental facts that when stimulated by different agonists, thecytosolic Ca2+ oscillations of hepatocytes show nearly constantamplitude for two different oscillation-form, simple spikes and complexbursts, we build a new 4-variables model based on the two modelsproposed by Hoefer [Biophys J. 77 (1999) 1244] and Kummeret al. [Biophys. J. 79 (2000) 1188] Our model cansimulate both simple-spike and multi-spike-burst oscillations withamplitude of 0.5-0.7 µmol/L in a rather wide range of parameters.
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