Abstract
Sartoria hedysaroides Boiss and Heldr. (Fabaceae) is an endemic plant of Turkey that has received little scientific consideration so far. In the present study, the chemical profiles of extracts from the aerial part and roots of S. hedysaroides obtained using solvents with different polarities were analyzed combining integrated NMR, LC-DAD-MSn, and LC-QTOF methods. In vitro antioxidant and enzyme inhibitory activities were evaluated, and the results were combined with chemical data using multivariate approaches. Phenolic acids, flavonoids, ellagitannins, and coumarins were identified and quantified in the extracts of aerial part and roots. Methanolic extract of S. hedysaroides aerial part showed the highest phenolic content and the highest antioxidant activity and cupric ion reducing antioxidant capacity. Dichloromethane extract of S. hedysaroides roots showed the highest inhibition of butyryl cholinesterase, while methanolic extract of S. hedysaroides aerial part was the most active tyrosinase inhibitor. Multivariate data analysis allowed us to observe a good correlation between phenolic compounds, especially caffeoylquinic derivatives and flavonoids and the antioxidant activity of extracts. Acetylcholinesterase inhibition was correlated with the presence of caffeoylquinic acids and coumarins. Overall, the present study appraised the biological potential of understudied S. hedysaroides, and provided a comprehensive approach combining metabolomic characterization of plant material and multivariate data analysis for the correlation of chemical data with results from multi-target biological assays.
Highlights
Nowadays, the use of medicinal plants is increasing among people having little access to modern healthcare, and by urban citizens from developed countries [1].This trend has been observed concurrently with the increase in the number of scientific articles reporting the benefits of herbal extracts
The extracts prepared from the aerial part possessed higher Total phenolic content (TPC) and total flavonoid content (TFC) compared with those obtained from the roots
To the best of our knowledge, there are no data on antioxidant properties of S. hedysaroides, and our results provide a valuable contribution to the scientific literature regarding this plant species
Summary
The use of medicinal plants is increasing among people having little access to modern healthcare, and by urban citizens from developed countries [1]. This trend has been observed concurrently with the increase in the number of scientific articles reporting the benefits of herbal extracts. The Fabaceae family contains over 490 species, many of which have ethnopharmacological importance due to their peculiar chemical constituents, which can promote the healthy functioning of bodily systems [3,4].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
