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Abstract
Acute Ischemic Stroke (AIS) is defined as the acute condition of occlusion of a cerebral artery and is often caused by a Hypertensive Condition (HC). Due to its sudden occurrence, AIS is not observable the right moment it occurs, thus information about instantaneous changes in hemodynamics is limited. This study aimed to propose an integrated Lumped Parameter (LP) model of the cardiovascular system to simulate an AIS and describe instantaneous changes in hemodynamics. In the integrated LP model of the cardiovascular system, heart chambers have been modelled with elastance systems with controlled pressure inputs; heart valves have been modelled with static open/closed pressure-controlled valves; eventually, the vasculature has been modelled with resistor-inductor-capacitor (RLC) direct circuits and have been linked to the rest of the system through a series connection. After simulating physiological conditions, HC has been simulated by changing pressure inputs and constant RLC parameters. Then, AIS occurring in arteries of different sizes have been simulated by considering time-dependent RLC parameters due to the elimination from the model of the occluding artery; instantaneous changes in hemodynamics have been evaluated by Systemic Arteriolar Flow (Qa) and Systemic Arteriolar Pressure (Pa) drop with respect to those measured in HC. Occlusion of arteries of different sizes leaded to an average Qa drop of 0.38 ml/s per cardiac cycle (with minimum and maximum values of 0.04 ml/s and 1.93 ml/s) and average Pa drop of 0.39 mmHg, (with minimum and maximum values of 0.04 mmHg and 1.98 mmHg). In conclusion, hemodynamic variations due to AIS are very small with respect to HC. A direct relation between the inverse of the length of the artery in which the occlusion occurs and the hemodynamic variations has been highlighted; this may allow to link the severity of AIS to the length of the interested artery.
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