Abstract
Hemodynamics is recognized as a relevant factor in the development and rupture of cerebral aneurysms, so further studies related to different physiological conditions in human represent an advance in understanding the pathology and rupture risk. In this paper, Fluid-structure interaction simulations (FSI) were carried out in six models of cerebral aneurysms, in order to study the hemodynamics effects of an isolated systolic hypertension (ISH) condition and compare it to a normal or normotensive pressure condition and a higher hypertension condition. Interestingly, the ISH condition showed, in general, the greatest hemodynamics changes, evidenced in the Time-Averaged Wall Shear Stress (TAWSS), Oscillatory Shear Index (OSI), and Relative Residence Time (RRT) parameters, with respect to a normal condition. These results could imply that a not high-pressure condition (ISH), characterized with a different shape and an abrupt change in its diastolic and systolic range may present more adverse hemodynamic changes compared to a higher-pressure condition (such as a hypertensive condition) and therefore have a greater incidence on the arterial wall remodeling and rupture risk.
Highlights
A cerebral aneurysm is an abnormal dilation of the artery caused by a weakness on the wall and is located on the subarachnoid space at the base of the brain
Fluid–structural simulations (FSI) simulations performed under normal blood and high blood pressure conditions showed that Wall shear stress (WSS) and mechanical stresses in the aneurysm wall were strongly affected by hypertension [10]
In A-5 there were only minor changes between the three different pressure conditions, and with hypertension presenting a slightly decrease in contrast to a normal condition. This behavior for A-3 and A-5 model showed that fluid–solid interaction phenomena and so the hemodynamics effects and magnitudes on the arterial wall were strongly dependent on the aneurysm type and geometry
Summary
A cerebral aneurysm is an abnormal dilation of the artery caused by a weakness on the wall and is located on the subarachnoid space at the base of the brain. A reduction of the tunica media and middle muscular layer on the artery wall, combined with hemodynamic factors, lead to this process [1]. Wall shear stress (WSS), oscillatory shear index (OSI), and relative residence time (RRT) have been proposed as indicators of aneurysm rupture risk [2,3,4,5]. Fluid–structural simulations (FSI) using image-based models of cerebral aneurysms can help to better understand the vascular remodeling processes associated with aneurysm growth and its subsequent stabilization or rupture [6,7]. FSI simulations performed under normal blood and high blood pressure conditions showed that WSS and mechanical stresses in the aneurysm wall were strongly affected by hypertension [10]
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