An Insight into the Increasing Role of LncRNAs in the Pathogenesis of Gliomas.

Yuanliang Yan,Zhicheng Gong,Lunquan Sun,Zhijie Xu,Zhi Li

doi:10.3389/fnmol.2017.00053

Abstract

Long non-coding RNAs (LncRNAs) are essential epigenetic regulators with critical roles in tumor initiation and malignant progression. However, the roles and mechanisms of aberrantly expressed lncRNAs in the pathogenesis of gliomas are not fully understood. With the development of deep sequencing analyses, an extensive amount of functional non-coding RNAs has been discovered in glioma tissues and cell lines. Additionally, the contributions of several lncRNAs, such as Hox transcript antisense intergenic RNA, H19 and Colorectal neoplasia differentially expressed, previously reported to be involved in other pathogenesis and processes to the oncogenesis of glioblastoma are currently addressed. Thus, lncRNAs detected in tumor tissues could serve as candidate diagnostic biomarkers and therapeutic targets for gliomas. To understand the potential function of lncRNAs in gliomas, in this review, we briefly describe the profile of lncRNAs in human glioma research and therapy. Then, we discuss the individual lncRNA that has been under intensive investigation in glioma research, and the focus is its mechanism and clinical implication.

Highlights

Glioblastoma (GBM) is the most common primary intracranial tumor, with varying malignancy grades and histological subtypes
The apoptosis rate of the glioma cell lines is shown to dramatically increase (Han et al, 2016a; Xiang et al, 2016). These results indicate that an investigation into the abnormal expression profiles of long non-coding RNAs (lncRNAs) may help in the understanding of oncogenesis and identify novel potential treatment targets in glioma research and therapy
A large-scale expression study of functional ultra-conserved ncRNAs showed that the uc.283 lncRNA, a 277 nucleotide-long sequence located at ultra-conserved regions (UCRs) of human genes, is highly specific for pluripotent stem cells, as well as some solid cancers, gliomas (Galasso et al, 2014)

Summary

Introduction

Glioblastoma (GBM) is the most common primary intracranial tumor, with varying malignancy grades and histological subtypes. These results indicate that an investigation into the abnormal expression profiles of lncRNAs may help in the understanding of oncogenesis and identify novel potential treatment targets in glioma research and therapy.

Results

Conclusion