An injectable hydrogel based on MOF-derived hollow nanocomposites for starvation and gas therapy cooperated phototherapy

Abstract

Here, glucose oxidase was loaded into Cu/Zn-MOF and then modified with polydopamine to obtain final nanoparticles (MGPs) with a size of approximately 150 nm. Under 808 nm laser irradiation, MGPs (0.125 mg mL−1) could rapidly increase 35.7 °C within 10 min, while generating large amounts of 1O2, and inducing starvation in the tumor microenvironment. L-arginine, as a precursor of NO, was incorporated into chitosan hydrogel together with MGP to allow for controlled release of NO under laser irradiation. Both in vitro and in vivo experiments demonstrated that an injectable hydrogel combining starvation and gas therapy with phototherapy effectively inhibited solid tumors growth.