Abstract
Push-pull is a canonical computation of excitatory cortical circuits. Here we identify a pull-push inhibitory circuit in frontal cortex that originates in vasoactive intestinal polypeptide (VIP) expressing interneurons. During arousal, VIP cells rapidly and directly inhibit pyramidal neurons; VIP cells also indirectly excite these pyramidal neurons via parallel disinhibition. Thus, arousal exerts a feed-back pull-push influence on excitatory neurons – an inversion of the canonical push-pull of feed-forward input.
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