An informatics perspective on cerebral cortical connectivity and function

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Event Abstract Back to Event An informatics perspective on cerebral cortical connectivity and function David C. Van Essen1* 1 Washington University School of Medicine, United States One of the great scientific challenges of the 21st century is to elucidate how the wiring of the human brain accounts for our unique cognitive capabilities and for individual differences in a wide variety of behavioral capacities. Recent advances on a variety of fronts, from data acquisition to neuroinformatics, will enable rapid progress on this daunting problem. The core data acquisition methods involve two powerful and complementary tools for analyzing human brain connectivity in vivo: tractography, which is based on diffusion imaging (DI), and functional connectivity analysis, which is based on spatial correlations in resting-state fMRI BOLD signals (R-fMRI). This presentation will discuss progress and challenges in using these methods to chart brain connectivity and to parcellate cerebral cortex based on differential patterns of connectivity (Fig. 1). This includes novel methods of data acquisition, analysis, and visualization, plus informatics enhancements for storing and communicating vast amounts of connectivity data. Several approaches to evaluating and validating connectivity data will be discussed. This includes comparisons with tracer-based connectivity maps acquired in nonhuman primates and registered to human cortex using plausible homologies between species. Collectively, these approaches are likely to yield deep insights into the fundamental basis of human brain function in health and disease. Conference: Neuroinformatics 2010 , Kobe, Japan, 30 Aug - 1 Sep, 2010. Presentation Type: Oral Presentation Topic: INCF Japan-Node Special Symposium "How Neuroinformatics can revolutionize Neuroscience" Citation: Van Essen DC (2010). An informatics perspective on cerebral cortical connectivity and function. Front. Neurosci. Conference Abstract: Neuroinformatics 2010 . doi: 10.3389/conf.fnins.2010.13.00141 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 21 Jun 2010; Published Online: 21 Jun 2010. * Correspondence: David C Van Essen, Washington University School of Medicine, Washington, United States, vanessen@brainvis.wustl.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers David C Van Essen Google David C Van Essen Google Scholar David C Van Essen PubMed David C Van Essen Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.