Abstract
Present investigation was planned to evaluate the effect of ethanol extract of leaves of Centella asiatica (CA) on neutrophil phagocytic function. The various concentrations (25, 50 and 100 mg/ml) of the extract was subjected to study its effect on different in vitro methods of phagocytosis such as neutrophil locomotion and chemotaxis, immunostimulant activity by phagocytosis of killed Candida albicans and qualitative nitro blue tetrazolium test using human neutrophils. The results of this preliminary study revealed that CA extract has stimulated chemotactic, phagocytic and intracellular killing potency of human neutrophils at the concentration range of 25-100 mg/ml. These results suggest that the ethanol extract of CA stimulates cell-mediated immune system by increasing neutrophil phagocytic function.
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