Abstract
Rhomboid proteases are ubiquitous intramembrane serine proteases that directly cleave misfolded membrane substrates within the lipid bilayer. They have vast functions in growth factor signaling, mitochondrial homeostasis, protein quality control and parasite invasion. Amongst the rhomboid proteases, Rhbdl4’s biological function has been the most characterized. Rhbdl4 has been demonstrated to play a critical role in removing misfolded proteins from the Endoplasmic Reticulum (ER) and and have been implicated in severe diseases such as breast cancer progression and Alzheimer’s disease.
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