Abstract
Omega-3 fatty acid plays a vital role as precaution agents in order to control depression and hyper cholesterol while act as an anti-inflammatory sensor. It binds to GPR120 and PPARγ proteins which inhibit phosphorylation of NFκB protein. In this research docking studies of PPARγ with omega-3 fatty acids, biochanin A and genistein including the docked complexes of PPARγ and selected ligands with NFκB are done. Furthermore, GPR120 was docked with all ligands and complexes of GPR120 and selected ligands with NFκB after which the best result was analyzed based upon the complimentary score of geometric shape, approximate atomic contact energy and interface area of complex. It was predicted that PPARγ has shown HPA (heneicosapentaenoic acid), ETE (eicosatrienoic acid)and ETA (eicosatetraenoic acid) as best leads and GPR120 showed heneicosapentaenoic acid (HPA), eicosatetraenoic acid (ETA), eicosatrienoic acid (ETE) as the best leads according to the geometric shape configuration of omega 3-fatty acid.
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