An in-Depth Review of Dercum’s disease: Aetiology, Epidemiology, and Treatment

Abstract

The purpose of the present review is to proffer a comprehensive overview of Dercum's disease (DD), a rare medical condition typified by the presence of excruciating subcutaneous adipose tissue deposits. The ambit of this exposition encompasses the delineation of the clinical features, diagnostic criteria, and treatment options for DD. DD is a complex and poorly understood ailment, thereby rendering its diagnosis a daunting task, primarily on account of the indeterminate character of its symptoms. Nonetheless, the timely identification of DD is crucial to stave off its advancement and ameliorate the standard of living of those afflicted by it. Diagnostic criteria have been posited for DD, and diagnostic imaging modalities, such as magnetic resonance imaging (MRI), have proven efficacious in facilitating the diagnosis of this malady. The treatment of DD is primarily palliative, geared toward assuaging pain and enhancing the overall quality of life. Therapeutic options comprise the administration of nonsteroidal anti-inflammatory drugs (NSAIDs) and opioids, local anesthetics, weight management strategies, and alterations to lifestyle choices.