An immediate release tablet of carvedilol with natural superdisintegrants fenugreek seed mucilage and synthetic superdisintegrants

Abstract

In many formulations, we start moving towards the Ayurvedic powders and other excipients, although it is good because the chances of adulteration can be decrease and patient compliance can be increased. And Immediate Release Tablets are those tablets which are designed to disintegrate and release their medication with no special rate controlling features, such as special coatings and other techniques. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because they are easy to administer, has quick onset of action is economical and lead to better patient compliance. In this research work on immediate release tablet Carvedilol and natural superdisintegrants (fenugreek seed mucilage) were prepared by wet granulation method. When work is started, Preformulation studies show us that powder blend is not having floating nature. Formulation was optimized and prepare under minimum possible disintegrating time. Tablets then further evaluated for FT-IR, solubility, hardness, weight variation, friability, wetting time, In vitro process, and for this we design nine formulations. In first three there is a Crospovidone, another three contain natural superdisintegrant (fenugreek seed mucilage), and for last three contain SSG. All were gone through pre and post compression method. All the prepared formulations show significant result obtained by Pharmacopoeia quality control test. On the basis of disintegration test observations F3 and F6 formulation were found to be best among all batches.