Abstract
Objective: In the present study, the effects of a natural superdisintegrant gellan gum, karya synthetic gum superdisintegrants like sodium starch glycolate, crospovidone and combination of natural and synthetic superdisintegrant were compared in the formulations of rizatriptan benzoate oral dispersible tablets.
 Methods: This oral dispersible tablets were prepared by direct compression method and evaluated for weight variation, hardness, disintegration time, drug content, friability and dissolution. Drug compatibility with excipients was checked by FTIR studies. Stability study of the prepared tablets was done at 40±2°/75%±5% RH for a period of 1 mo.
 Results: FTIR studies showed that no any chemical interaction between drugs and excipients. The in vitro drug release study revealed that formulation F9 combination of both crospovidone and karya gum was the most successful formulation and disintegrate time within 13 seconds and drug release within 10 min. The drug release from the best formulations followed first-order kinetics, which is concentration-dependent. Short terms stability studies of the tablet for three months showed non-significant drug loss.
 Conclusion: The formulation containing a combination of natural and synthetic superdisintegrant was found to be the best results. Apart from fulfilling all official and other specifications, the tablets exhibited a higher rate of drug release.
Highlights
Nowadays, or dispersible drug delivery systems are comprehensively used to expand bioavailability and patient compliance
Oral dispersible tablets of Rizatriptan Benzoate were prepared by direct compression technique according to the formula given in table 1
FTIR spectroscopic studies indicated that the drug is compatible with all the excipients
Summary
Dispersible drug delivery systems are comprehensively used to expand bioavailability and patient compliance. Over the past three years, or dispersible tablets (ODTs) have gained considerable attention as a desired substitute to conventional tablets and capsules due to better patient compliance, improved solubility and stability profiles. ODTs are solid dosage forms containing medicinal substances that disintegrate rapidly, usually within seconds, when placed on the tongue with or without the intake of water [1]. Super disintegrants are added to a drug formulation to simplify the breakup or disintegration of tablet or capsule content into smaller particles that can dissolve more rapidly than in the absence of disintegrants. Drug absorbed via “oral cavity” directly enters into systemic circulation by a jugular vein ensuring, a rapid onset of action, avoidance of the first-pass metabolism, and drug degradation in gastric region and enzymatic hydrolysis in the intestine. The various technologies used to prepare ODT’s include direct compression, sublimation, tablet molding, spray drying, freeze-drying and mass extrusion [3]
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