Abstract
Distant brain metastases from oral squamous cell carcinomas (OSCC) are extremely rare. Here we describe a case of a 53-year-old man with a primary OSCC who referred to the neurosurgical department because of epileptic seizures. MR imaging revealed an enhancing lesion in the right parietal lobe. A craniotomy with tumor removing was performed. Histopathological examination verified an invasive, minimally differentiated metastasis of the primary OSCC. The patient refused whole brain radiation therapy and died from pulmonary metastatic disease 10 months after the neurosurgical intervention without any cerebral recurrence. To the authors' knowledge, only two similar cases have been previously reported.
Highlights
Remote brain metastases from oral squamous cell carcinomas (OSCC) are an extremely rare occurrence
We describe a case of a 53-year-old man with a primary OSCC who referred to the neurosurgical department because of epileptic seizures
MR imaging revealed an enhancing lesion in the right parietal lobe
Summary
Remote brain metastases from oral squamous cell carcinomas (OSCC) are an extremely rare occurrence. Direct intracranial invasion is not infrequent in patients with nasopharyngeal carcinoma (NPC) at a locally advanced stage [3]. Incidence of brain metastases following NPC may be increasing secondary to advancements in the treatment of systemic disease and earlier detection by more sensitive imaging modalities [4]. Most distant metastases from squamous cell carcinoma (SCC) are reported to occur in the liver, lungs, and bones [5]. In the following case study, we present a patient who developed a histologically confirmed brain metastasis of OSCC. The patient developed symptoms from his cerebral metastasis 29 months after the primary disease was diagnosed
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