Abstract
Herein, we report the experimental study emerged on the encapsulation of polyether compounds such as mephenesin (MEP) into the nano hydrophobic cage of β-cyclodextrin as host molecule. The commonly known co-precipitation method was followed to prepare inclusion complex (IC) by molar ratio 1:1. Different spectrometric techniques e.g. transform infrared spectroscopy (FTIR), DSC, TGA, DTA and scanning electron microscope (SEM) indicated molecular interactions between β-CD and MEP. UV–visible titration predicts the binding constant for βCD and MEP in solution state around 2.1 × 103 M−1. The formation of the inclusion complex has been predicted by slight shifts in the FTIR as well as 1H NMR spectrum. Job plot and ESI-MS spectra showed that 1:1 inclusion complex has been formed. Molecular docking study unveils the inclusion mechanism which is well supported with the experimental data. In addition, UV–visible spectroscopic study predicts the binding interaction between mephenesin with amino acid residues of BSA and DNA.
Published Version
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