An Exploration of ChCl/Glycerol-Based Deep Eutectic Solvent as a Sustainable Reaction Medium for the Synthesis of Biologically Important Aminopyrazole and Aminopyrazolone Compounds

Abstract

Objectives: the synthesis of 4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)- 4h-pyrazol-3,5-diamine and 3-amino-4-((1-phenyl-3-(substitutedphenyl)-1h-pyrazol-4-yl) methylene)-1h-pyrazol-5(4h)-one was designed and performed very aptly in deep eutectic solvent system. Methods: the utilization of deep eutectic solvent (des) system chcl/gly (1:2) in the absence of hazardous organic co-solvents, an efficient multicomponent one-pot synthetic strategy has been advanced. In addition to that, from the perspectives of sustainable developments in organic synthesis, the deep eutectic solvent system was recovered and very efficiently reused up to four cycles. Results: it has been observed that the efficacy of the deep eutectic solvent was decreased after the second cycle, which has a measurable impact on the yield of the reaction. Conclusion: furthermore, the synthesized aminopyrazole and aminopyrazolone compounds were screened as antibacterial and antifungal agents.