Abstract
An investigation has been conducted on the antiandrogenic properties of BOMT ∗ ∗ a list of abbreviations is given in the references; to avoid confusion in the Text between the stereoisomers of dihydrotestosterone, 5α-dihydrotestosterone is abbreviated to DHT throughout. . This steroid selectively suppresses the nuclear binding of 5α-dihydrotestosterone (DHT) ∗ in androgen-dependent tissues, in vitro. In addition, BOMT competes effectively for the specific, high affinity binding sites for DHT in the cytoplasm of the rat prostate gland and reduces the transfer of DHT into chromatin in a reconstituted, cell-free system. BOMT also antagonises the stimulation of RHA polymerase activity in the prostate gland after the administration of testosterone, in vivo. Conversely, BOMT had no effect on the rate of formation of DHT in androgen-dependent tissues. On the basis of these studies, it is suggested that the antiandrogenic properties of BOMT are best explained by its competition for the DHT-binding sites in androgen-dependent tissues.
Published Version
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