Abstract
This chapter presents experiments for possible cortical cholinergic link in the electroencephalogram (EEG) arousal reaction that were performed on 90 adult albino rabbits weighing between 2.5 to 3.0 kg. The topical application of the cholinolytic drugs benactyzine, scopolamine and atropine blocked previously established EEG alerting evoked by eserine or pilocarpine administered intravenously. The cholinolytic drugs also evoked synchronization when alerting was induced by peripheral stimulation as well as after the electrical stimulation of the midbrain. In addition, the cholinolytic drugs were effective in blocking alerting induced by i.v. amphetamine and 5-hydroxytryptophan. Carbocaine as well as pontocaine, and the latter is a far more potent anesthetic than either atropine or benactyzine, failed to interfere with arousal patterns. It is therefore suggested that the ability of the cholinolytic drugs we used to interfere with the EEG alerting reaction is a specific effect and not due to local anesthesia.
Published Version
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