Abstract
Objective: To evaluate the effect of comprehensive intervention by health education and medical intervention to dyslipidemia Uyghur patients in low-income rural areas in Xinjiang, China. Method: A multistaged (prefecture-county-township-village) stratified cluster random sampling method was used to select participants in southern Xinjiang. Twelve villages in Jiangbazi Township in Jiashi County were chosen. These villages were randomly divided into six intervention groups and six control groups, and local Uyghur aged 18 years or older residing in the village for at least 6 months were interviewed for a baseline prevalence study and to select participants for two years of comprehensive intervention including low dose simvastatin and the effects of the interventions were observed. Results: A total of 655 participants (347 participants in the intervention groups, 308 participants in the control groups) were randomly selected from 12 villages in Jiangbazi Township, follow-up rate is 87.0%. Compared to baseline mean levels of TG and LDL-C were reduced by 1.39 mmol/L (p < 0.01) and 2.12 mmol/L (p < 0.01) respectively and levels of HDL-C increased by1.22 mmol/L (p < 0.01) in the intervention group. Lipids were controlled in 38.61% of the intervention groups vs. 3.57% of the control groups (p < 0.01). Compared with baseline lipid levels, TG, TC, LDL-C and HDL-C was significantly improved, compared with it was in control groups. Conclusions: Blood lipid levels of Uygur patients with dyslipidemia can be effectively improved through health education combined with low-dose statin administration. This suggests that national strategies in public health be developed to improve the treatments to low-income rural minorities with dyslipidemia.
Highlights
Cardiovascular disease (CVD) is one of the major contributions to mortality in developed and developing countries, especially in low- and middle-income countries [1,2,3]
Organization has estimated that cardiovascular disease (CVD) accounted for more than 30% of deaths around the world in 2008, and almost 25 million people are expected to die of cardiovascular disease in
12 villages in Jiangbazi Township were selected to represent the Muslim Uyghur in rural areas. These villages were randomly divided into six intervention groups and six control groups, and we interviewed local Uyghur residents aged 18 years or older in the villages over six months to conduct a baseline prevalence survey
Summary
Cardiovascular disease (CVD) is one of the major contributions to mortality in developed and developing countries, especially in low- and middle-income countries [1,2,3]. Numerous studies have shown that the prevalence of dyslipidemia was relatively high during the last decade, and the percentage of adults with awareness, treatment and control of dyslipidemia were low in China [5,6,7,8]. With relatively underdeveloped economic and limited health resources, there have not been serious studies to analyze local public health needs including long-term monitoring for patients with dyslipidemia and provide patients with treatment which is appropriated to their needs. Due to differences in religion, culture, lifestyle, diet, and genetic background in Uyghur, effective and practicable comprehensive interventions for patients might have a positive meaning for reducing associated complications and improved the health in preventive public health for inhabitant residents in Xinjiang. To better help dyslipidemia patients control blood lipid levels, our researchers performed regular health education and provided lipid-lowering drugs to adjust the lipid levels for local dyslipidemia patients, and raised awareness, treatment and control of dyslipidemia between May 2009 and November 2012, which have important implications in preventive public health for medically underserved Muslim minorities
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