Abstract
Human plasma fraction IV-1 contains an enzyme that rapidly inactivates bradykinin and kallidin II. The activity of the enzyme was characterized with biological and chemical techniques; it inactivates bradykinin by breaking its Phe 8.Arg 9 bond.Zn 2+ or Co 2+ can reactivate the enzyme, which is inhibited by chelating agents, but Co 2+ is the only accelerator found. Numerous other compounds inhibit only. The enzyme in human red blood cells that destroys bradykinin is different from the plasma enzyme. The suggestion was made to name the enzyme in human plasma fraction IV-1 “carboxypeptidase N”.
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