Abstract
Metal doped nanoparticles as a modifier have received attention in the development of electrochemical sensors and biosensors. In the current work, we established the electrochemical behaviour and detection of clozapine by utilizing 2.0% silver doped TiO2 nanoparticles modified carbon paste electrode (Ag-TiO2/CPE) at pH 4.2 by employing different voltammetric techniques. Modification enhances the electro-oxidation of clozapine with increased current intensity. The characterization of silver doped titanium dioxide nanoparticles was accomplished by utilizing X-ray diffraction (XRD), scanning electron microscope (SEM), Energy-dispersive X-ray spectroscopy (EDX) and transmission electron microscope (TEM). The influence of parameters like scan rate, pH, accumulation time, amount of the modifier and concentration on the peak current of the drug were studied. The effect of CLZ concentration variation was studied using square wave voltammetric (SWV) technique and got lowest detection limit compared to reported techniques. The fabricated sensor was employed for the determination of clozapine in pharmaceutical and biological samples
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