Abstract

An active link: A diglycine-containing linker (cat⋅linker) was fabricated on Rink amide resin for dual functions: a) attachment of a scaffold and b) capture of metal ions for promoting on-resin reactions (see picture). The metal-catching feature of the linker proves essential for the solid-phase synthesis of indoles through microwave-assisted CuII-mediated heteroannulation.

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