Abstract
Revolution in organic compound synthesis has been promoted by microwave assisted organic syntheses (MAOS) by which small molecules are built up into large polymers in a fraction of time. The need for different organic compound libraries for drug discovery, biomaterial development, automated library screening; proteomics etc has supported the emergence of innovative technologies for rapid combinatorial organic synthesis using MAOS synthesis. In previous reviews on this subject the focus of MAOS has been on the process of MAOS reactions rather than the importance given to the related applications. This review focuses on solid-phase synthesis, biopolymer synthesis, applications in proteomics, parallel processing in microwave reactors and automated library generation by means of sequential microwave irradiation methods. This article has discussed the different applications of Microwave assisted synthesis of organic polymeric compounds most thoroughly by focusing on aspects of speed, reproducibility and scalability. From this review it is clearly identified that independent on the type of organic material, data consistently points out to MW as a novel and powerful tool which has enable synthesis of a number of new compounds and presents the need for future research in this area.
Highlights
Revolution in organic compound synthesis has been promoted by microwave assisted methods by which small molecules are built up into large polymers in a fraction of time when compared to thermal methods ensuring the acceptance of Microwave assisted irradiation reactions as a valuable tool for acceleration of a wide variety of organic molecules development (Mavandadi & Pilioti, 2006; Tsoleridis et al, 2011)
Revolution in organic compound synthesis has been promoted by microwave assisted organic syntheses (MAOS) by which small molecules are built up into large polymers in a fraction of time
This review focuses on solid-phase synthesis, biopolymer synthesis, applications in proteomics, parallel processing in microwave reactors and automated library generation by means of sequential microwave irradiation methods
Summary
Revolution in organic compound synthesis has been promoted by microwave assisted methods by which small molecules are built up into large polymers in a fraction of time when compared to thermal methods ensuring the acceptance of Microwave assisted irradiation reactions as a valuable tool for acceleration of a wide variety of organic molecules development (Mavandadi & Pilioti, 2006; Tsoleridis et al, 2011). The ability to reduce reaction time from days and hours to minutes using microwave assisted reactions has promoted advent of microwave technology in combinatorial chemistry (Santagada et al, 2004; Kappe, 2004) and drug discovery (Sekhon et al, 2010; Santagada et al, 2009) as there is reliance on generation of large number of compounds whose production has been diversified as well as enhanced due to MAOS as there is increased production of cleaner reactions and more pure products (Bogadal et al, 2003; Mosely et al, 2007) Some of the novel areas where MOAS has been applied have been focused including solid-phase synthesis, biopolymer synthesis, applications in proteomics, parallel processing in microwave reactors and automated library generation by means of sequential microwave irradiation methods
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