Abstract

Abstract Crystals of a human γG1 immunoglobulin molecule have been examined in an electron microscope. The micrograph exhibits periodicities in several directions corresponding to the repeating unit in the crystal lattice. A series of two optical integrations of the micrograph in two directions virtually eliminates the random noise and the repeating molecules become clearly visible. The overall appearance of the molecule is characterized by three globular units, presumably corresponding to one Fc and two Fab portions. These units are assembled to give a complete molecule having a form ranging from a Y to a T. This is in agreement with previous electron microscope studies and with the x-ray diffraction studies of these crystals.

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