An efficient triethyl phosphite-promoted one-pot synthesis of vicinal diamines from arylglyoxals and aniline derivatives

Abstract

An effective protocol for synthesis of some new vicinal diamine derivatives is reported through a one-pot reaction between arylglyoxals and aniline derivatives promoted by triethyl phosphite as a reductive coupling reagent. All reactions were conducted in ethanol as solvent at room temperature and the stable solid products were obtained by simple filtering off the precipitated solids in high yields. The structures of all products were proved by 1H and 13C NMR and IR spectral and elemental analysis data.