An Efficient Synthesis of Fused Polycyclic Triazolo[4,5-a]acridine Derivatives under Catalyst-Free Conditions with High Regioselectivity

Abstract

An efficient synthesis of fused polycyclic 11-aryl-7,8,9,11-tetrahydro-1H-[1,2,3] triazolo[4,5-a]acridin-10(6H)-one derivatives is described in EtOH with high regioselectivity. This new procedure includes a three-component reaction of benzaldehyde, 1H-benzo[d] [1,2,3]triazol-5-amine and cyclohexane-1,3-dione under catalyst-free conditions, and has the advantages of one-pot reaction, milder reaction conditions, high yields and high regioselectivity.