Abstract
A three-component reaction of benzaldehyde, methyl 5-aminobenzofuran-2-carboxylate, and cyclohexane-1,3-dione in refluxing EtOH under catalyst-free conditions regioselectively gave furo[3,2-a]acridine rather than furo[3,2-b]acridine derivatives. This new procedure has the advantages of one-pot reaction, catalyst-free nature, high yield, and high regioselectivity.
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