Abstract
A novel and efficient quinoline-based fluorescent chemosensor (QLSA) for zinc(II) ion (Zn2+) detection was reported. This sensor was facilely synthesized via a simple linker NH2–NH2 connected quinoline-2-carboxylic acid and salicylaldehyde. This non-fluorescent quinoline derivative can detect Zn2+ with high sensitivity and favorable specificity and lead to significant fluorescence OFF–ON switching. The detection limit for Zn2+ was found to be 2.1×10−8M. The mechanism of the interaction between the sensor and Zn2+ has been investigated in detail through NMR and HRMS analysis. The sensor exhibited low cytotoxicity and larger Stokes shifts (171nm) which are important and desired features for a fluorophore in live-cell imaging. Moreover, further application of the sensor in fluorescence imaging was studied in Hela cell by confocal fluorescence microscopy, suggesting that the sensor was proved to be a useful tool for tracking Zn2+ levels in vivo.
Published Version
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