An efficient platform based on cupper complex-multiwalled carbon nanotube nanocomposite modified electrode for the determination of uric acid

Abstract

A new voltammetric sensor for determination of uric acid (UA) by Cupper complex- multiwalled carbon nanotube (Cu-complex-CNT) nanocomposite modified carbon paste electrode (CPE) is reported. The electrocatalytic behavior of the Cu-complex-CNT nanocomposite modified CPE were studied in pH 2.0 phosphate buffer solution by chronoamperometry (CA) and cyclic voltammetry (CV) in the presence of uric acid. Due to the excellent electrocatalytic activity, enhanced electrical conductivity and high surface area of the Cu-complex-CNT, determination of uric acid with well-defined peaks was achieved at the Cu-complex-CNT modified electrode. The catalytic peak current obtained, was linearly dependent on the UA concentrations in the range of 0.66 – 350.0µM with sensitivity of 0.05 µA µM-1. The detection limits for UA were 0.075µM, The diffusion coefficient for the oxidation of UA at the modified electrode was calculated as (4.1±0.05) ×10−5 cm2 s−1. The proposed sensor was successfully examined for real sample analysis with urine and human serum and revealed stable and reliable recovery data.