An Efficient Combinatorial Synthesis of Novel Thiazolidinone‐Bis Schiff Base Hybrids Using One‐Pot Multicomponent Reaction

Abstract

AbstractA facile multicomponent synthesis of novel thiazolidinone‐bis Schiff base hybrids has been developed using readily available starting materials. The four‐component reaction of isothiocyanate, hydrazine, aldehyde and α‐bromoester in water readily affords thiazolidinone‐bis Schiff base hybrids, whereas the five‐component strategy involving the same reactants in the presence of boron trifluoride etherate in acetonitrile leads to the formation of the fully functionalized thiazolidinone‐bis Schiff base hybrids.