An efficient and one-pot green synthesis of novel 6-oxo-7-aryl-6,7-dihydrochromeno pyrano[2,3-b]pyridine derivatives

Abstract

A simple and efficient protocol has been developed for the construction of novel 6-oxo-7-aryl-6,7-dihydrochromenopyrano[2,3-b]pyridine derivatives using one-pot, three-component cyclocondensation of 4-hydroxycoumarin, various aromatic aldehydes and 2-aminoprop-1-ene-1,1,3-tricarbonitrile using 10 mol % guanidine hydrochloride as the organocatalyst under solvent-free conditions at 90 °C for the first time. The significant features of this protocol are operational simplicity, provide good to high yields, avoidance of toxic solvents, straightforward work-up, no column chromatographic purification and atom-economy which is considered to be relatively environmentally benign.