An efficient and facile approach for the construction of chondroitin sulfate E oligosaccharide precursors

Abstract

An efficient and facile approach has been developed for the construction of chondroitin sulfate E (CS-E) oligosaccharide precursors. In this approach, the disaccharide unit with the GalNAc-GlcA sequence was first elongated to form tetra- and hexasaccharides followed by the introduction of anomeric groups via glycosylation couplings. A number of CS-E tetra- and hexasaccharide precursors were prepared in high yields.