An Efficient and Environmentally Benign One-pot Three- Component Domino Protocol for the Synthesis of Structurally Diverse Spiroquinazolines

Abstract

An efficient and environmentally benign diversity oriented synthetic protocol has been presented for the synthesis of structurally diverse spiroquinazolines. The hybrid druglike molecules incorporating medicinally privileged heterocyclic systems (spiroquinazolinespirooxindoles) have been synthesized by three-component reaction of isatoic anhydride, aromatic amines and substituted isatins using gluconic acid aqueous solution (GAAS, 50%, wt%) as an efficient, inexpensive and eco-friendly bio-based catalytic solvent system. Keywords: Diversity oriented synthesis, environmentally benign synthetic protocol, spiroquinazoline-spirooxindoles, gluconic acid aqueous solution (GAAS, 50%, wt%).