An effective proposal plantherapy forthe treatment of schistosomiasisinTaiz Governorate

Abstract

Background: Schistosomiasis is one of the most common diseases in Yemen, especially in Taiz, and it is a serious infection that causes many organic damages including cirrhosis of the liver, enlargement of the spleen, gastrointestinal bleeding and an increased risk of bladder cancer. There are several treatments for schistosomiasis in the initial stages through a specific dose and during a short period, and the most famous of the schistosomiasis drugs is praziquantel. According to the known treatment plan, praziquantel eliminates only adult schistosomiasis, but it is not effective in killing eggs and immature worms, and therefore the treatment of praziquantel is repeated after 4 -6 weeks to ensure complete eradication of the parasite, but with that there are many cases that have not been treated. Methods: In this research, three methods were provided to treat schistosomiasis. The first method was given the first group according to the general protocol Praziquantel 40 mg per kilogram as a single dose, which is the most used method of treatment. As for the second method, Praziquantel was used twice a week at a dose of 40 mg / kg.While the third method proposed in the research, two drugs were proposed, namely the Praziquantel and the prednisone, and a protocol was placed for treatment, where the Praziquantel was prescribed at a dose of 40 mg / kg on the first day and was reduced to 20 mg / kg for 6 days. As for the treatment with prednisone, it was prescribed by 20 mg per day for a week, then it decreases to 10 mg / day for a week after that. Results: The tests were conducted on a group of schistosomiasis patients, including 450 patients. The patient group was divided into 3 groups in each group of 150 patients. The three methods were applied to the three groups. The results of the first group were the number of healing cases 40 cases from 150 patients, while the healing cases of the second group were 90 cases from 150 patients. Finally, the results of the third group, which is the proposed method is better than the results of the first group and the second group, where healing cases were 100 percent. Conclusion: Through the results, the third group proposed in the research proved that it is more effective and healing rate of up to 100 percent . Keywords: schistosomiasisPraziquantel,.