An effective diagnosis of schizophrenia using kernel ridge regression-based optimized RVFL classifier

Abstract

Schizophrenia (SCZ) is a severe mental and debilitating neuropsychiatric disorder that disrupts a person’s thought processes, emotions, and behavior. Due to misdiagnosis, self-denial, and social stigma, many SCZ cases go untreated. Magnetic resonance imaging (MRI) is an excellent noninvasive tool for soft tissue contrast imaging because it provides crucial data on tissue structure size, position, and shape. The Resnet50 network is a deep residual learning framework used for feature extraction. Random-vector functional link network (RVFL) is an example of a single-hidden-layer feedforward network in which input features and hidden layer features are fed to the output layer. In this paper, we introduced a kernel ridge regression-based random vector functional link (KRR-RVFL) classifier which focuses on addressing the linearity issues in RVFL by designating the kernel function in the input layer for the precise diagnosis of SCZ. The genetic algorithm (GA) seeks to minimize the loss function by optimizing the weights and biases of the KRR-RVFL network. The classification performance is investigated on the SCZ and cognitive normal (CN) subjects, collected from the available open neuro platform, including 99 participants. The results of the suggested network show superior performance to the recent state-of-the-art networks in terms of accuracy 93.66%, sensitivity 92.22%, specificity 95.17%, precision 95.33%, F-measure 93.74%, and G-mean 93.68%. The performance metrics demonstrated the applicability of this framework for assisting clinicians in the automatic, precise evaluation of SCZ.