Abstract
In two different ovarian preparations in vivo, androstenedione-C 14 was infused via the left ovarian artery of the dog. In such animals, estradiol-C 14 and estrone-C 14 could be isolated from the venous blood of the infused organ. If clomiphene was infused via the left ovarian artery concomitant with androstenedione-C 14, the rate of conversion of androstenedione-C 14 to estradiol-C 14 and to estrone-C 14 increased. Clomiphene, moreover, increased the ovarian production of estradiol from non-radioactive precursors. The data are discussed with regard to possible mechanism of action of clomiphene on endocrine organs.
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