Abstract
Dehydroepiandrosterone-sodium sulfate (DHEA-sodium sulfate) labeled with tritium in 7α position has been infused at a constant rate by the left ovarian or spermatic artery in anesthetized dogs pretreated with human chorionic gonadotropin for 10 days. Testosterone and Δ4-androstenedione were isolated in the venous blood from the gonads in both sexes, while free dehydroepiandrosterone was isolated only in the female animal. 1.1. The canine ovary and testis are able to convert DHEA-sodium sulfate to testosterone and Δ4-androstenedione in vivo.2.2. No conversion from DHEA-sodium sulfate to estrogens could be detected.3.3. The significance of this reaction is discussed.
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Schedule a callMore From: Biochimica et Biophysica Acta (BBA) - General Subjects
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