An eco-friendly synthesis of polyhydroquinoline derivatives using MoO3 promoted CeO2-ZrO2 solid heterogeneous catalyst

Abstract

The molybdenum (8–20 wt%) (MoO3) promoted CeO2-ZrO2 (ceria-zirconia) solid solutions were prepared using precipitation and impregnation method, calcined at 500 °C. The catalytic potency of synthesized materials were tested for the synthesis of polyhydroquinoline derivatives using a mixture of various aromatic aldehydes, dimedone, and ethyl acetoacetate and ammonium acetate in ethanol under reflux condition. Amazingly, it was observed that with increasing Mo wt% loading increases the excellent yield of product this may be due to acidic nature of MoO3. Particularly, the 20 wt% MoO3 promoted CeO2-ZrO2 catalyst exhibited promising catalytic activity in terms of excellent yield of the products with short reaction time. The present methods significantly contributed as efficient and eco-friendly method for the synthesis of polyhydroquinoline derivatives.