Abstract
Catalysis of the isomerization of the symmetrical adduct 1 by (+)-camphor-10-sulfonic acid in chloroform gave (−)- 2, which was enriched by fractional crystallization techniques and purified by column chromatography. Values for the optical purity of this sample were obtained both by conversion into diastereomers and by the isotopic dilution method, and were in fair agreement with one another. They corresponded to an enantiomeric excess of 1·34% in the original synthesis. In benzene as solvent the (+)-enantiomer was preferentially formed.
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