An association study between protein kinase B gene intron polymorphism and citalopram antidepressant effect

Abstract

Objective To examine the association between protein kinase Bet gene first,second and forth intron polymorphism and citalopram antidepressant clinical efficacy and side effects.Methods The subjects comprised 104 patients according to the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-IV)criteria for major depressive disorder.The clinical efficacy and side effects were assessed on 1 week,2 weeks,4 weeks after eitalopram treatment.PCR and DNA sequencing analysis were used to detect the genotype of PKB.SPSS13.0 statistic software was used to statistic analysis.Results ①An association was found between PKBα rs2494738 and citalopram antidepressant effect(alleles:OR=0.139,P=0.011);and the major depressive disorders patient carrying G alleles showed the better effect of citalopram treatment than individual carrying A allele.②A weak association was revealed between the genotype of rs2494738 and adverse dry mouth(X~2=6.730,P=0.035).Conclusion The PKBα rs2494738 polymorphism may associate with citalopram antidepressant efficacy and side effects. Key words: Major depressive disorders; Protein kinase Bα; Single nucleotide polymorphisms (SNPs); Citalopram