Tacrolimus binding proteins 5 gene polymorphisms in major depressive disorder

Abstract

Objective Tacrolimus binding proteins 5 (FKBP5) gene polymorphisms were analyzed in Chinese Han major depressive disorder (MDD) patients. Methods 263 major depressive disorder (MDD) patients who met the Diagnostic and Statistical Manual of Mental Disorders 4thEdition (DSM-Ⅳ) criterion were given antidepressant drugs for six weeks.The patients were divided into two groups of the responder group and the non-responder group,according to the decreasing rate of score of HAMD≥50% and<50% respectively.Genomic DNA was extracted from the blood samples,when patients being enrolled.Two polymorphisms (rs3800373 and rs1360780) of FKBP5 gene were genotyped using the ligase detection reaction. Results (1) The distribution frequencies of the SNP of rs3800373 showed no significant differences between responder group (GG+ GT 45.7%; TT 54.3%) and non-responder group (GG+ GT 47.6%;TT 52.4%)(χ2=0.051,P>0.05).The distribution frequencies of the SNP of rs1360780 showed no significant differences between responder group (CC 55.6%;CT+TT 44.4%) and non-responder group (CC 51.2%;CT+ TT 48.8%)(χ2=0.256,P>0.05). (2) No significant differences were found in rs3800373-rs1360780 haplotype frequencies between responder group and non-responder group (P>0.05). (3) There were no significant differences in the incidence rate of total side effect and nausea adverse effect between the patients with different genotypes of rs3800373 and rs1360780 (P>0.05). Conclusions There may be no significant differences in the genotype frequencies of FKBP5 gene rs3800373 and rs1360780 polymorphisms between responder group and non-responder group in Chinese Han MDD patients. Key words: Depressive disorder; Tacrolimus binding proteins; Genes; Polymorphism,restriction fragment length