AN ASSESSMENT ON BUCCAL MUCOADHESIVE DRUG DELIVERY SYSTEM

Leela Lakshmi V,Umashankar M S,Alagusundaram M

doi:10.22159/ijap.2021v13i6.42760

Leela Lakshmi V, Umashankar M S + Show 1 more

Open Access

https://doi.org/10.22159/ijap.2021v13i6.42760

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Abstract

Buccal drug delivery system (BDDS) has won a variety of exposure and traction as it possesses plenty of advantages and benefits as evaluate to different mucosal drug delivery systems. Buccal path for systemic drug delivery, the use of mucoadhesive polymers twill significantly increase the efficacy of many tablets, has been of outstanding interest over the previous couple of decades. This article affords a precise of BDDS mechanisms, consisting of a composition of the oral mucosa, delivery mechanism, numerous forms of BDDS, formulation, assessment and application of BDDS. Additionally, this text affords a precis over the patents, advertised products and destiny factors of BDDS. In this evaluation article, we've got tried to assemble the maximum significant reports (1988 to 2021) of formulation, assessment, application, patents of BDDS. This review will help pharmaceutical researchers to clarify the potential of BDDS to overcome the various existing drug delivery dispute like the efficiency of absorption, permeability and bioavailability of drugs.

Highlights

Advancement and the progress made by the pharmaceutical industry that greatly contributed to treat the diseases, improving the quality of life [1]
The Buccal drug delivery system predominantly serves more advantages when compared to controlled drug delivery
It was a promising area for the systemic drug delivery of orally inefficient drugs

Summary

INTRODUCTION

Advancement and the progress made by the pharmaceutical industry that greatly contributed to treat the diseases, improving the quality of life [1]. Transmucosal method of drug transmission comprise of the mucosal lining of mouth, eye, vagina, rectum and nasal cavity which provides potential benefits over oral systemic drug delivery system. These features include the ability to bypass the first-pass metabolism, avoid the pre-elimination of the drug in the GI tack and dependence on the drug characters, it shows better enzymatic flora for the drug absorption [4]. 1 and table 1, it show the composition of the oral cavity and its respective role in drug penetration It covers the soft palate, ventral surface of the tongue, inner lip, floor of the mount and inner cheeks.

Connective Tissue

Saliva

Permeation enhancer

Enzyme inhibitor

Method used

CONCLUSION