An antipyretic action of aureomycin; inhibition of febrile response to influenza virus in rabbits.

Abstract

SummaryIntraperitoneal or intravenous injection of aureomycin prevented the febrile reaction of rabbits to intravenous inoculation of influenza B virus, but administration of aureomycin by gavage did not consistently prevent fever. Although intraperitoneal injection of aureomycin reduced rectal temperature below normal, the data suggest that this hypothermic action of the drug was not responsible for the antipyretic effect observed. Aureomycin did not alter the development of tolerance to the pyrogen. Intraperitoneal aureomycin also modified the febrile response of rabbits to a bacterial pyrogen, typhoid bacilli.